The Nikkei 225 Index slipped 0.5% to around 42,100 while the broader Topix Index eased 0.2% to 3,076 on Wednesday, giving up prior gains and mirroring Wall Street’s retreat. US equities sank overnight amid climbing global bond yields, mounting economic uncertainties and renewed trade tensions. At home, Bank of Japan Deputy Governor Ryozo Himino said Tuesday the central bank should keep raising rates gradually but stressed that global risks remain elevated, suggesting no urgency for aggressive tightening. Investors now await fresh Japanese wage figures later this week for signals on the policy outlook. Losses were pronounced among index heavyweights including SoftBank Group (-3.4%), Mitsubishi Heavy Industries (-2.5%), Advantest (-1.1%), Tokyo Electron (-1.2%) and Sanrio (-1.3%).