European equity markets were set to open lower on Tuesday, reversing gains from the previous session as hopes for de-escalation in the Middle East conflict faded after Iran denied holding talks with the US to end the standoff. Iran continued strikes on US assets in the region, while Israel launched fresh attacks against Iran and Lebanon. Global equities had rebounded on Monday after President Donald Trump postponed planned strikes on Iranian energy infrastructure for five days and claimed that productive talks were underway. In Europe, investors will assess manufacturing data from across the region for insight into how businesses are coping with heightened geopolitical uncertainty. In premarket trade, Euro Stoxx 50 and Stoxx 600 futures were down 0.7% and 0.9%, respectively.